Noll Richard
Department of Social Sciences, DeSales University, Center Valley, PA 18034-9568, USA.
Hist Psychiatry. 2007 Sep;18(71 Pt 3):301-20. doi: 10.1177/0957154X07078705.
Kraepelin believed that a chronic metabolic autointoxication, perhaps arising from the sex glands, eventually caused chemical damage to the brain and led to the symptoms of dementia praecox. The evolution of Kraepelin's autointoxication theory of dementia praecox is traced through the 5th to 8th (1895 to 1913) editions of his textbook, Psychiatrie. The historical context of autointoxication theory in medicine is explored in depth to enable the understanding of Kraepelin's aetiological assumption and his application of a rational treatment based on it--organotherapy. A brief account of the North American reception of Kraepelin's concept of dementia praecox, its autotoxic basis, and the preferred American style of rational treatment--surgery--concludes the discussion.
克雷佩林认为，一种慢性代谢性自体中毒，可能源于性腺，最终会对大脑造成化学损伤，并导致早发性痴呆的症状。通过他的教科书《精神病学》第5版至第8版（1895年至1913年）追溯了克雷佩林早发性痴呆自体中毒理论的演变。深入探讨了医学中自体中毒理论的历史背景，以便理解克雷佩林的病因假设以及他基于此的合理治疗方法——器官疗法的应用。对北美对克雷佩林早发性痴呆概念及其自体中毒基础的接受情况，以及美国人偏爱的合理治疗方式——手术，进行了简要介绍，作为讨论的结尾。
