Dashniani M, Beselia G, Maglakelidze G, Burjanadze M, Naneishvili T
I. Beritashvili Institute of Physiology, Tbilisi.
Georgian Med News. 2007 Nov(152):52-6.
This experiment investigated the ability of sham-operated and medial septal (MS) damaged rats to learn the location of a visible, as well as submerged platform in a water maze. The rats' responses on the competition test were classified as either cue or place, based on the swim path for those trials. Sham-operated rats acquired both the visible and hidden platform versions of the task, but when required to choose between the spatial location they had learned and the visible platform in a new location majority of them swam first to the old spatial location. The MS damaged rats acquired the visible platform version of the water maze task but failed to learn the platform's location in space. When the visible platform was moved to a new location they often swam directly to it. Sham-operated rats identified as place responders had significantly more accurate searches during hidden platform training, providing additional evidence of their effective use of a place learning strategy than MS is damaged. These findings suggest that in the absence of a septohippocampal functional system behaviour was not affected by spatial information and responding to local reinforced cues was enhanced. These data add to a growing literature demonstrating that the septo-hippocampal system is essential for accurate spatial learning and suggest its role in processing information about the spatial environment.
本实验研究了假手术大鼠和内侧隔区（MS）损伤大鼠在水迷宫中学习可见平台以及水下平台位置的能力。根据那些试验中的游泳路径，将大鼠在竞争测试中的反应分类为线索反应或位置反应。假手术大鼠学会了任务的可见平台和隐藏平台版本，但当需要在它们所学的空间位置和新位置的可见平台之间进行选择时，大多数大鼠首先游向旧的空间位置。MS损伤大鼠学会了水迷宫任务的可见平台版本，但未能学会平台在空间中的位置。当可见平台移到新位置时，它们常常直接游向该位置。被确定为位置反应者的假手术大鼠在隐藏平台训练期间的搜索明显更准确，这比MS损伤大鼠更有力地证明了它们有效运用位置学习策略。这些发现表明，在缺乏隔海马功能系统的情况下，行为不受空间信息的影响，对局部强化线索的反应增强。这些数据进一步丰富了越来越多的文献，表明隔海马系统对于准确的空间学习至关重要，并暗示了其在处理有关空间环境信息方面的作用。
