Ferramosca Alessandra, Savy Viviana, Zara Vincenzo
Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce-Monteroni, Lecce, Italy.
Biosci Biotechnol Biochem. 2008 Jan;72(1):62-9. doi: 10.1271/bbb.70369. Epub 2008 Jan 7.
Diet supplementation with olive oil exerts beneficial effects on an organism, even if an increase in the level of hepatic lipids has been concomitantly observed. This study was therefore designed to investigate whether the stimulation of lipogenesis was responsible for the olive oil-induced hepatic fat accumulation. In mice fed for 8 weeks with an olive oil-enriched diet, an increase of about 2.6 fold in the level of liver triglycerides was found in comparison to animals fed with a corn oil-containing diet. Despite that, no increase in the activities of cytosolic lipogenic enzymes or of the mitochondrial tricarboxylate carrier was found; on the contrary, a decrease in the activity of carnitine palmitoyltransferase I was observed. This impairment of fatty acid oxidation, which was not apparent in corn oil-fed animals, may have had a role in the increase of hepatic lipid content found in the olive oil-fed mice.
用橄榄油进行饮食补充对机体具有有益作用，即便同时观察到肝脏脂质水平有所升高。因此，本研究旨在调查脂肪生成的刺激是否是橄榄油诱导肝脏脂肪积累的原因。在用富含橄榄油的饮食喂养8周的小鼠中，与用含玉米油饮食喂养的动物相比，肝脏甘油三酯水平增加了约2.6倍。尽管如此，未发现胞质脂肪生成酶或线粒体三羧酸载体的活性增加；相反，观察到肉碱棕榈酰转移酶I的活性降低。这种脂肪酸氧化的损害在喂食玉米油的动物中并不明显，可能在喂食橄榄油的小鼠肝脏脂质含量增加中起了作用。
