Kawakami Eiichi, Hirano Taichi, Hori Tatsuya, Tsutsui Toshihiko
Laboratory of Veterinary Reproduction, Nippon Veterinary and Life Science University, Kyonan-cho, Tokyo, Japan.
J Vet Med Sci. 2007 Dec;69(12):1259-62. doi: 10.1292/jvms.69.1259.
The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively. The rate of occurrence of SCT in the cryptorchid testis was very high (71%). The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis. The mean SOD activity in cryptorchid testes and SCTs was significantly lower and higher, respectively, than in normal testes (both P<0.01). The mean HSP 70 concentration in both cryptorchid testes and SCTs was significantly higher than in normal testes (both P<0.01). The mean plasma INH-alpha concentration of the cryptorchid and SCT dogs was significantly lower and higher, respectively, than in normal dogs (P<0.05 and 0.01, respectively). The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.
50只患有单侧睾丸肿瘤的犬中，支持细胞瘤（SCT）、精原细胞瘤和间质细胞瘤的比例分别为52%、36%和12%。隐睾中支持细胞瘤的发生率非常高（71%）。为了确定犬隐睾中支持细胞瘤发生的高危因素，对10只单侧隐睾且无睾丸肿瘤的犬、10只单侧隐睾患有支持细胞瘤的犬和10只5至15岁的正常犬的睾丸超氧化物歧化酶（SOD）活性、睾丸热休克蛋白（HSP）70浓度和外周血血浆抑制素（INH）-α浓度进行了测量。隐睾和支持细胞瘤中的平均SOD活性分别显著低于和高于正常睾丸（均P<0.01）。隐睾和支持细胞瘤中的平均HSP 70浓度均显著高于正常睾丸（均P<0.01）。隐睾犬和支持细胞瘤犬的平均血浆INH-α浓度分别显著低于和高于正常犬（分别为P<0.05和0.01）。隐睾中低SOD活性、隐睾犬低血浆INH-α浓度以及支持细胞瘤中高HSP 70浓度可能与犬隐睾中支持细胞瘤的发生和肿瘤细胞增殖有关。
