Jung Dong-In, Kang Byeong-Teck, Park Chul, Yoo Jong-Hyun, Gu Su-Hyun, Jeon Hyo-Won, Kim Ju-Won, Heo Ra-Young, Sung Hyun-Jeong, Eom Ki-Dong, Lee Jong-Hwan, Woo Eung-Je, Park Hee-Myung
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
J Vet Med Sci. 2007 Dec;69(12):1303-6. doi: 10.1292/jvms.69.1303.
Administration of immunosuppressive doses of glucocorticosteroids is the traditional primary treatment in necrotizing meningoencephalitis (NME) in dogs. However, response is variable and clinical signs often recur quickly with tapering dosage. Prognosis is poor and long-term therapy causes many complications. In the present study, we compared the long-term effects of combination (cyclosporine plus prednisolone) therapy with sole prednisolone therapy in management in dogs with NME. All NME cases in this study were examined with magnetic resonance imaging and cerebrospinal fluid analysis, and confirmed by histopathologic examination. The mean survival time of combination therapy group was 305.7 +/- 94.7 days. The mean survival time of sole prednisolone therapy group was 58.3 +/- 30.5 days. This case report demonstrates that combination treatment of cyclosporine with prednisolone is more effective in survival time than administration of only prednisolone in NME cases.
给予免疫抑制剂量的糖皮质激素是犬坏死性脑膜脑炎（NME）的传统主要治疗方法。然而，治疗反应存在差异，且随着剂量逐渐减少，临床症状往往很快复发。预后较差，长期治疗会引发许多并发症。在本研究中，我们比较了联合治疗（环孢素加泼尼松龙）与单独使用泼尼松龙治疗对患有NME犬的长期影响。本研究中的所有NME病例均通过磁共振成像和脑脊液分析进行检查，并经组织病理学检查确诊。联合治疗组的平均生存时间为305.7±94.7天。单独使用泼尼松龙治疗组的平均生存时间为58.3±30.5天。本病例报告表明，在NME病例中，环孢素与泼尼松龙联合治疗在生存时间方面比仅使用泼尼松龙更有效。
