Kohno Emiko, Nishikata Mayumi, Okamura Noboru, Matsuyama Kenji
Department of Pharmacy, Kansai Medical University Takii Hospital, Fumizono-cho, Moriguchi, Osaka, Japan.
Yakugaku Zasshi. 2008 Jan;128(1):111-5. doi: 10.1248/yakushi.128.111.
Prostaglandin E(1) (PGE(1); Alprostadil Alfadex) is a potent vasodilator and inhibitor of platelet aggregation used to treat patients with peripheral vascular disease. The main adverse effects of intravenous PGE(1) administration, phlebitis and venous pain, arise from the unphysiologically low pH of infusion solutions. When PGE(1) infusion solutions with a pH value greater then 6 are used, phlebitis and venous pain are considered to be avoidable. Beginning with a PGE(1) infusion solution with pH greater than 6, we add the amount of 7% sodium bicarbonate needed to bring the solution to pH 7.4 if phlebitis or venous pain develops. In the present study we established a convenient nomogram showing the relationship between the titratable acidity of various infusion solutions and the volume of 7% sodium bicarbonate required to attain pH 7.4 for preventing the phlebitis and venous pain associated with PGE(1) infusion.
前列腺素E(1)（PGE(1)；前列地尔 alfadex）是一种强效血管扩张剂和血小板聚集抑制剂，用于治疗外周血管疾病患者。静脉注射PGE(1)的主要不良反应，即静脉炎和静脉疼痛，源于输注溶液的pH值过低，不符合生理状态。当使用pH值大于6的PGE(1)输注溶液时，静脉炎和静脉疼痛被认为是可以避免的。从pH值大于6的PGE(1)输注溶液开始，如果出现静脉炎或静脉疼痛，我们添加所需的7%碳酸氢钠量，以使溶液的pH值达到7.4。在本研究中，我们建立了一个方便的列线图，显示了各种输注溶液的可滴定酸度与达到pH值7.4所需的7%碳酸氢钠体积之间的关系，以预防与PGE(1)输注相关的静脉炎和静脉疼痛。
