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Deletion of ultraconserved elements yields viable mice.
PLoS Biol. 2007 Sep;5(9):e234. doi: 10.1371/journal.pbio.0050234.
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Human genome ultraconserved elements are ultraselected.
Science. 2007 Aug 17;317(5840):915. doi: 10.1126/science.1142430.
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Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression.
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Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons.
J Neurosci. 2007 May 9;27(19):5012-22. doi: 10.1523/JNEUROSCI.4725-06.2007.
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In vivo enhancer analysis of human conserved non-coding sequences.
Nature. 2006 Nov 23;444(7118):499-502. doi: 10.1038/nature05295. Epub 2006 Nov 5.
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Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants.
Nat Genet. 2006 Oct;38(10):1216-20. doi: 10.1038/ng1888. Epub 2006 Sep 24.
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Close sequence comparisons are sufficient to identify human cis-regulatory elements.
Genome Res. 2006 Jul;16(7):855-63. doi: 10.1101/gr.4717506. Epub 2006 Jun 12.
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Conserved noncoding sequences are selectively constrained and not mutation cold spots.
Nat Genet. 2006 Feb;38(2):223-7. doi: 10.1038/ng1710. Epub 2005 Dec 25.
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A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts.
Genome Res. 2005 Aug;15(8):1061-72. doi: 10.1101/gr.4004805. Epub 2005 Jul 15.
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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.
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