Saydam Birsen K, Goksel Gamze, Korkmaz Esra, Kapkac Murat, Ozdemir Necmettin, Sezgin Canfeza, Uslu Ruchan
Womens Health Nursing, Izmir Ataturk School of Health, Ege University, Bornova Izmir, Turkey.
Saudi Med J. 2008 Jan;29(1):81-6.
To compare initial metastatic breast carcinoma (MBC) with recurrent MBC and assess their biologic phenotypes and clinical behaviors.
A comparison of clinical and biological characteristics and median overall survival times were assessed in the 251 patients with MBC at the Division of Medical Oncology, Ege University School of Medicine, and the Division of Radiation Oncology, Tepecik Government Hospital, Izmir, Turkey between 1995 and 2004. Hormone receptors, c-erbB-2, Ki-67, and p53 expressions were performed by immunohistochemistry.
Out of 251 MBC patients, 206 patients had recurrent MBC, and 45 had initial MBC. Regarding survival, there was no difference between the recurrent MBC group and the initial MBC group. The initial MBC group had a higher proportion of T4 tumors (46% versus 27%), a lower proportion of T1-2 tumors (31% versus 55%; p=0.01), and a higher percentage of patients with high Ki-67 expression (64% versus 49%; p=0.05). Multivariate analysis showed that T stage was an independent prognostic factor (p=0.02).
Patients with initial MBC tended to present with larger tumors. This relationship can be explained by delayed diagnosis. The potential for reducing death rates from breast cancer is contingent on educational improvement and increased screening rates.
比较初发性转移性乳腺癌（MBC）和复发性MBC，并评估其生物学表型和临床行为。
对1995年至2004年间在土耳其伊兹密尔埃杰大学医学院医学肿瘤学教研室和特佩奇克政府医院放射肿瘤学教研室的251例MBC患者的临床和生物学特征以及中位总生存时间进行比较。通过免疫组织化学检测激素受体、c-erbB-2、Ki-67和p53的表达。
在251例MBC患者中，206例为复发性MBC，45例为初发性MBC。在生存方面，复发性MBC组和初发性MBC组之间没有差异。初发性MBC组T4期肿瘤比例较高（46%对27%），T1-2期肿瘤比例较低（31%对55%；p=0.01），Ki-67高表达患者百分比更高（64%对49%；p=0.05）。多因素分析显示T分期是一个独立的预后因素（p=0.02）。
初发性MBC患者倾向于出现更大的肿瘤。这种关系可以用诊断延迟来解释。降低乳腺癌死亡率的潜力取决于教育水平的提高和筛查率的增加。
