Meda Francesca, Zuin Massimo, Invernizzi Pietro, Vergani Diego, Selmi Carlo
Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy.
Autoimmunity. 2008 Feb;41(1):27-34. doi: 10.1080/08916930701619227.
The widespread use of serum autoantibodies in the practice of clinical hepatology has led to novel challenges in the interpretation of results obtained with routine techniques, such as indirect immunofluorescence (IIF) or with recombinant antigens. In fact, the laboratory methods are often overlooked factors in the interpretation of data by the bedside clinician despite being critical in the interpretation of data. Importantly, the sensitivity and specificity of these serum hallmarks are not defined in all cases. Taken altogether, these observations point towards the need for a systematic discussion of autoimmune serology in the clinical setting of everyday practice. The target of this review article is therefore, to illustrate the current knowledge and available experimental evidence to guide the diagnostic and prognostic decision making in autoimmune and viral chronic liver diseases.
血清自身抗体在临床肝病实践中的广泛应用给常规技术（如间接免疫荧光法（IIF）或重组抗原技术）所获结果的解读带来了新挑战。事实上，尽管实验室方法对数据解读至关重要，但床边临床医生在解读数据时往往忽略这些因素。重要的是，这些血清标志物的敏感性和特异性并非在所有情况下都已明确。综上所述，这些观察结果表明在日常临床实践中需要对自身免疫血清学进行系统讨论。因此，本文综述的目的是阐述当前的知识和现有实验证据，以指导自身免疫性和病毒性慢性肝病的诊断和预后决策。
