Guevara R, Valle A, Gianotti M, Roca P, Oliver J
Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.
Horm Metab Res. 2008 Jan;40(1):38-43. doi: 10.1055/s-2007-1004525. Epub 2008 Jan 7.
In the present study, we have investigated whether differences between male and female rats described in response to 40% caloric restriction (CR) were influenced by circulating level variations of sex hormones and/or insulin and leptin. Body weights (BW), organ weights, and adipose depot weights (ADW) were also measured. The most affected tissues by CR were the fat depots. Metabolically active organs were the least affected, especially more in females than in males (male weight lost: 24.3% vs. female: 17.3%). Testosterone and estradiol circulating levels did not show changes by CR. Insulin levels were decreased by CR in both genders, but was more evident in female rats than males. Leptin serum levels were higher in male rats than in females, and CR caused a circulating leptin level reduction only in males. In conclusion, our results indicate that leptin and insulin could be one of the keys of the different hormonal control of energy homeostasis in response to CR between female and male rats. In this sense, leptin serum levels correlated statistically with BW and with individual ADW only in male rats, whereas insulin serum levels correlated statistically with BW and with any of the ADW studied only in females.
在本研究中，我们调查了雄性和雌性大鼠在40%热量限制（CR）反应中所描述的差异是否受到性激素、胰岛素和瘦素循环水平变化的影响。还测量了体重（BW）、器官重量和脂肪储存重量（ADW）。受CR影响最大的组织是脂肪储存部位。代谢活跃的器官受影响最小，尤其是雌性比雄性更明显（雄性体重减轻：24.3%，雌性：17.3%）。睾酮和雌二醇的循环水平未因CR而发生变化。CR使两性的胰岛素水平均降低，但在雌性大鼠中比雄性更明显。雄性大鼠的瘦素血清水平高于雌性，CR仅使雄性大鼠的循环瘦素水平降低。总之，我们的结果表明，瘦素和胰岛素可能是雌性和雄性大鼠对CR反应中能量稳态不同激素控制的关键因素之一。从这个意义上说，仅在雄性大鼠中，瘦素血清水平与BW和个体ADW具有统计学相关性，而仅在雌性大鼠中，胰岛素血清水平与BW和所研究的任何ADW具有统计学相关性。
