Xu Y-D, Ou Y-K, Zheng Y-Q, Zhang S-Y
Department of Otolaryngology, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China.
J Laryngol Otol. 2008 Nov;122(11):1175-9. doi: 10.1017/S0022215107001399. Epub 2008 Jan 7.
To investigate methods of treating diffuse osteoradionecrosis of the temporal bone in cases of nasopharyngeal carcinoma, following radiotherapy.
Retrospective.
Fourteen post-irradiation nasopharyngeal carcinoma patients (n = 14 ears) with diffuse osteoradionecrosis received surgical treatment from March 1994 to May 2005. The patients underwent radical mastoidectomy (five ears), extensive radical mastoidectomy (one ear), or radical mastoidectomy and obliteration with local vascularised fascia flaps (eight ears).
Six ears fully recovered; two ears were still infectious but sequestrum had not re-formed; five ears (50 per cent) still had repeated suppuration and did not epithelialise; and one ear had local re-formation of sequestrum requiring periodic dressing changes.
Diffuse osteoradionecrosis of the temporal bone following radiotherapy for nasopharyngeal carcinoma is difficult to treat surgically. The main objective of surgery is to facilitate drainage and to prevent complications. Radical mastoidectomy and obliteration with local vascularised flaps is an effective method.
探讨鼻咽癌放疗后颞骨弥漫性放射性骨坏死的治疗方法。
回顾性研究。
1994年3月至2005年5月,14例放疗后鼻咽癌伴颞骨弥漫性放射性骨坏死患者(共14耳)接受了手术治疗。患者接受了根治性乳突切除术(5耳)、扩大根治性乳突切除术(1耳)或根治性乳突切除术并采用局部带血管筋膜瓣填塞术(8耳)。
6耳完全恢复;2耳仍有感染,但死骨未再形成;5耳(50%)仍反复化脓且未上皮化;1耳局部死骨重新形成,需要定期换药。
鼻咽癌放疗后颞骨弥漫性放射性骨坏死手术治疗困难。手术的主要目的是促进引流并预防并发症。根治性乳突切除术并采用局部带血管瓣填塞术是一种有效的方法。