Kirkham Tim C
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK.
Cell Metab. 2008 Jan;7(1):1-2. doi: 10.1016/j.cmet.2007.12.006.
Endocannabinoid/cannabinoid receptor signaling acts centrally and peripherally to govern appetite and energy balance. While system stimulation promotes eating and energy storage, receptor blockade can reduce food intake and facilitate weight loss. In this issue of Cell Metabolism, Addy et al. (2008) test the therapeutic antiobesity potential of taranabant, a cannabinoid 1 receptor inverse agonist.
内源性大麻素/大麻素受体信号通路在中枢和外周发挥作用，调控食欲和能量平衡。该系统受到刺激时会促进进食和能量储存，而阻断该受体则可减少食物摄入量并促进体重减轻。在本期《细胞代谢》杂志中，阿迪等人（2008年）对大麻素1受体反向激动剂——替拉那班的抗肥胖治疗潜力进行了测试。
