转录增强因子1（TEF-1/TEAD1）介导BRGl对IFITM3基因的激活作用。
Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRGl.
作者信息
Cuddapah Suresh, Cui Kairong, Zhao Keji
机构信息
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
FEBS Lett. 2008 Jan 23;582(2):391-7. doi: 10.1016/j.febslet.2007.12.033. Epub 2008 Jan 3.
Abstract
The interferon inducible transmembrane (IFITM) proteins mediate several cellular processes such as homotypic cell adhesion functions of interferons (IFNs) and cellular anti-proliferative activities. We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor 1 (TEF-1/TEAD1) to the M-CAT like elements of its promoter. TEF-1 knock-down reduced the BAF complex-mediated activation of IFITM3 promoter. In the absence of the BAF complex, TEF-1 is repressive to IFITM3 expression. The regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes.
摘要
干扰素诱导跨膜（IFITM）蛋白介导多种细胞过程，如干扰素（IFN）的同型细胞粘附功能和细胞抗增殖活性。我们发现，BAF复合物介导的IFITM3诱导依赖于转录增强因子1（TEF-1/TEAD1）与其启动子的M-CAT样元件的结合。敲低TEF-1可降低BAF复合物介导的IFITM3启动子激活。在没有BAF复合物的情况下，TEF-1对IFITM3表达具有抑制作用。TEF-1对IFITM3的调控表明，TEF-1依赖性调控比其先前在肌肉特异性基因表达中所确立的作用更为广泛。
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