Krass Maarja, Wegener Gregers, Vasar Eero, Volke Vallo
Department of Physiology, University of Tartu, Tartu, Estonia.
Behav Brain Res. 2008 Apr 9;188(2):324-8. doi: 10.1016/j.bbr.2007.11.013. Epub 2007 Nov 24.
The aim of this study was to characterize the behavioral effects of systemically administered agmatine in animal models predictive of antidepressant- and anxiolytic-like activity and clarify whether the effects of agmatine depend on the intact serotonergic system. Only the highest dose of agmatine tested (50 mg/kg) decreased immobility of mice in the forced swimming test. The magnitude of the effect was slightly smaller than that of the tricyclic antidepressant imipramine (15 mg/kg). Agmatine did not change the locomotion of mice in the open field. Pretreatment with the tryptophane hydroxylase inhibitor PCPA for 3 days resulted in more than 70% drop in the tissue levels of 5-HT and 5-HIIA but did not counteract the antidepressant-like effect of agmatine. The administration of agmatine did not modify behavior of animals in the light-dark compartment test of anxiety. We conclude that the antidepressant-like effect of agmatine seems not to be mediated by the serotonergic system. We failed to confirm the reported anxiolytic-like activity of agmatine.
本研究的目的是在预测具有抗抑郁和抗焦虑样活性的动物模型中，表征全身给药胍丁胺的行为效应，并阐明胍丁胺的效应是否依赖于完整的血清素能系统。仅测试的最高剂量胍丁胺（50mg/kg）可减少强迫游泳试验中小鼠的不动时间。其效应强度略小于三环类抗抑郁药丙咪嗪（15mg/kg）。胍丁胺未改变小鼠在旷场中的活动。用色氨酸羟化酶抑制剂对氯苯丙氨酸预处理3天导致5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIIA）的组织水平下降超过70%，但并未抵消胍丁胺的抗抑郁样效应。在焦虑的明暗箱试验中，胍丁胺的给药并未改变动物的行为。我们得出结论，胍丁胺的抗抑郁样效应似乎不是由血清素能系统介导的。我们未能证实所报道的胍丁胺的抗焦虑样活性。
