Ebal E, Cavalié H, Michaux O, Lac G
Biologie des activités physiques et sportives (BAPS), laboratoire biologie B, Les Cézeaux, 63177 Aubière cedex, France.
Pathol Biol (Paris). 2008 Jul;56(5):283-5. doi: 10.1016/j.patbio.2007.09.002. Epub 2008 Jan 4.
Forty-eight 67-day-old male Wistar rats (330+/-5g) were fed ad libitum either with a lipid enriched diet or a standard laboratory chow. Half of each sub-group was submitted to training. Training and difference in diet composition induced nonsignificant changes in body adiposity. Visceral fat (perirenal adipose tissue mass) was correlated with leptin (r=0.35, p=0.02) and insulin (r=0.38, p=0.01). Total body fat mass (measured by DEXA) was correlated with leptin only (r=0.58, p=0.003). Other correlations between perirenal adipose tissue or fat mass and adiponectin or insulin like growth factor 1 were nonsignificant. These results suggest that, in rat like in human, visceral fat development is linked with insulin insensitivity.
