Attal Nadine
Inserm U-792, F-92100 Boulogne-Billancourt, France.
Presse Med. 2008 Feb;37(2 Pt 2):346-53. doi: 10.1016/j.lpm.2007.07.023. Epub 2008 Jan 4.
Neuropathic pain remains difficult to treat. Treatments with established efficacy in several neuropathic conditions include tricyclic antidepressants, gabapentin, pregabalin and strong opioids. Duloxetine and venlafaxine, both antidepressants, and tramadol, an opioid agonist, are also known to be effective in painful polyneuropathies, while lidocaine patches produce analgesic effects, mainly in postherpetic neuralgia. Studies show that pregabalin, gabapentin and duloxetine have positive effects that improve quality of life, and anxiety, depressive, and sleep disorders.
神经性疼痛仍然难以治疗。在几种神经性疾病中已证实有效的治疗方法包括三环类抗抑郁药、加巴喷丁、普瑞巴林和强效阿片类药物。度洛西汀和文拉法辛这两种抗抑郁药，以及阿片类激动剂曲马多，在疼痛性多发性神经病中也被认为是有效的，而利多卡因贴片主要在带状疱疹后神经痛中产生镇痛作用。研究表明，普瑞巴林、加巴喷丁和度洛西汀具有改善生活质量以及缓解焦虑、抑郁和睡眠障碍的积极作用。
