Madhavan Deepak, Mirowski Piotr, Ludvig Nandor, Carlson Chad, Doyle Werner, Devinsky Orrin, Kuzniecky Ruben
New York University Comprehensive Epilepsy Center, 403 East 34th Street, 4th Floor, New York, NY 10016, United States.
Epilepsy Res. 2008 Feb;78(2-3):235-9. doi: 10.1016/j.eplepsyres.2007.11.007. Epub 2008 Jan 4.
Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.
最近研究表明，将抗癫痫药物（AED）直接注入大鼠新皮质能够预防和终止局灶性癫痫发作。目前的临床实验旨在测试利多卡因对人类患者癫痫源区邻近软脑膜的局部作用。利多卡因给药后，所有患者的尖峰计数均显著减少，利多卡因对单个尖峰的高频成分和整个测试阶段具有递减作用。利多卡因直接应用于皮质似乎会影响难治性局灶性癫痫患者的局部癫痫源活动。
