Henneman Maureen M, Schuijf Joanne D, Dibbets-Schneider Petra, Stokkel Marcel P, van der Geest Rob J, van der Wall Ernst E, Bax Jeroen J
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Am J Cardiol. 2008 Jan 15;101(2):144-8. doi: 10.1016/j.amjcard.2007.07.084.
The aim of the study was to evaluate the performance of multislice computed tomography (MSCT) for the detection and semiquantitative analysis of healed myocardial infarct in comparison to single-photon emission computed tomography (SPECT). Recently, MSCT was shown to allow detection of myocardial infarct by the presence of hypoenhanced areas. However, direct comparisons to other imaging modalities for infarct imaging were scarce. In 69 patients with healed myocardial infarct (>3 months), the presence of myocardial infarct and infarct score was assessed using SPECT and MSCT. In addition, regional and global left ventricular function was assessed using MSCT. In 62 of 69 patients (90%), a perfusion defect was detected using gated SPECT at rest. Using MSCT in these 62 patients (100%), hypoenhanced areas reflecting infarct were shown. In 3 of 7 patients (43%) without perfusion defects who underwent gated SPECT, MSCT identified regions of infarct. The infarct score on MSCT related well to the SPECT infarct score (12 +/- 10% vs 16 +/- 13%; r = 0.93, p <0.0001). In addition, good (inverse) correlations were shown for infarct score using MSCT and parameters of left ventricular function. In conclusion, healed myocardial infarct can be detected accurately using MSCT, with good correlation with SPECT.
本研究的目的是评估多层螺旋计算机断层扫描（MSCT）与单光子发射计算机断层扫描（SPECT）相比，在检测愈合心肌梗死及进行半定量分析方面的性能。最近的研究表明，MSCT可通过低密度强化区域的存在来检测心肌梗死。然而，与其他梗死成像模态的直接比较却很少见。在69例愈合心肌梗死（>3个月）患者中，使用SPECT和MSCT评估心肌梗死的存在情况及梗死评分。此外，使用MSCT评估左心室局部和整体功能。69例患者中有62例（90%）在静息门控SPECT检查中发现灌注缺损。在这62例患者中使用MSCT（100%）显示出反映梗死的低密度强化区域。在7例接受门控SPECT检查且无灌注缺损的患者中有3例（43%），MSCT识别出梗死区域。MSCT上的梗死评分与SPECT梗死评分密切相关（12±10%对16±13%；r = 0.93，p<0.0
