具有（E）构型的新型手性氰基丙烯酸酯衍生物的合成及抗病毒活性
Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration.
作者信息
Chen Zhuo, Wang Xianyou, Song Baoan, Wang Hua, Bhadury Pinaki S, Yan Kai, Zhang Huiping, Yang Song, Jin Linhong, Hu Deyu, Xue Wei, Zeng Song, Wang Jun
机构信息
Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, PR China.
出版信息
Bioorg Med Chem. 2008 Mar 15;16(6):3076-83. doi: 10.1016/j.bmc.2007.12.035. Epub 2008 Feb 21.
The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.
中间体3在微波辐射下通过适当的芳基（杂环）胺的亲核进攻转化为标题化合物4的手性（E）异构体。这些化合物表现出弱至良好的抗烟草花叶病毒生物活性，其中（R）-4p在烟草叶片中显示出显著增强的抗病性。
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