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鉴定EspA N端结构域中在EspA丝状体生物发生和功能中起作用的氨基酸残基。

Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function.

作者信息

Singh Mona P, Shaw Robert K, Knutton Stuart, Pallen Mark J, Crepin Valerie F, Frankel Gad

机构信息

Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom.

出版信息

J Bacteriol. 2008 Mar;190(6):2221-6. doi: 10.1128/JB.01753-07. Epub 2008 Jan 4.

DOI:10.1128/JB.01753-07
PMID:18178741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258869/
Abstract

Enteropathogenic Escherichia coli employs a filamentous type III secretion system, made by homopolymerization of the translocator protein EspA. In this study, we have shown that the N-terminal region of EspA has a role in EspA's protein stability, interaction with the CesAB chaperone, and filament biogenesis and function.

摘要

肠道致病性大肠杆菌利用一种丝状III型分泌系统，该系统由转运蛋白EspA的同聚物聚合而成。在本研究中，我们已经表明，EspA的N端区域在EspA的蛋白质稳定性、与CesAB伴侣蛋白的相互作用以及丝状结构的形成和功能方面发挥作用。

相似文献

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Identification of amino acid residues within the N-terminal domain of EspA that play a role in EspA filament biogenesis and function.鉴定EspA N端结构域中在EspA丝状体生物发生和功能中起作用的氨基酸残基。
J Bacteriol. 2008 Mar;190(6):2221-6. doi: 10.1128/JB.01753-07. Epub 2008 Jan 4.
2
CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.CesAB是III型转运蛋白EspA和EspB的肠道致病性大肠杆菌伴侣蛋白。
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Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion.肠致病性大肠杆菌EspA丝状体组装和蛋白质分泌的极性
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Structural characterization of a type III secretion system filament protein in complex with its chaperone.与伴侣蛋白结合的III型分泌系统丝状蛋白的结构表征
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Substrate-activated conformational switch on chaperones encodes a targeting signal in type III secretion.伴侣蛋白构象激活开关编码 III 型分泌系统中的靶向信号。
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引用本文的文献

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Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). doi: 10.1073/pnas.2022826118.
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The Serine Protease EspC from Enteropathogenic Escherichia coli Regulates Pore Formation and Cytotoxicity Mediated by the Type III Secretion System.来自肠致病性大肠杆菌的丝氨酸蛋白酶EspC调节III型分泌系统介导的孔形成和细胞毒性。
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SepD/SepL-dependent secretion signals of the type III secretion system translocator proteins in enteropathogenic Escherichia coli.肠致病性大肠杆菌中III型分泌系统转运蛋白的SepD/SepL依赖性分泌信号
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本文引用的文献

1
Protein delivery into eukaryotic cells by type III secretion machines.通过III型分泌机制将蛋白质递送至真核细胞。
Nature. 2006 Nov 30;444(7119):567-73. doi: 10.1038/nature05272.
2
The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea.肠道致病性大肠杆菌III型分泌系统效应蛋白Map与EBP50/NHERF1结合：对细胞信号传导和腹泻的影响
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Citrobacter rodentium of mice and man.小鼠和人类的鼠柠檬酸杆菌
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Molecular basis of antigenic polymorphism of EspA filaments: development of a peptide display technology.EspA细丝抗原多态性的分子基础：一种肽展示技术的开发
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Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.肠道致病性和肠出血性大肠杆菌感染：易位，易位，易位。
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Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perspective.非鞭毛III型分泌系统的生物信息学、基因组学与进化：达尔文视角
FEMS Microbiol Rev. 2005 Apr;29(2):201-29. doi: 10.1016/j.femsre.2005.01.001.
7
Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion.肠致病性大肠杆菌EspA丝状体组装和蛋白质分泌的极性
J Bacteriol. 2005 Apr;187(8):2881-9. doi: 10.1128/JB.187.8.2881-2889.2005.
8
Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion.肠上皮细胞脱落位点的生物信息学分析为III型分泌提供了新见解。
BMC Microbiol. 2005 Mar 9;5:9. doi: 10.1186/1471-2180-5-9.
9
Structural characterization of a type III secretion system filament protein in complex with its chaperone.与伴侣蛋白结合的III型分泌系统丝状蛋白的结构表征
Nat Struct Mol Biol. 2005 Jan;12(1):75-81. doi: 10.1038/nsmb879. Epub 2004 Dec 26.
10
Type III flagellar protein export and flagellar assembly.III型鞭毛蛋白输出与鞭毛组装
Biochim Biophys Acta. 2004 Nov 11;1694(1-3):207-17. doi: 10.1016/j.bbamcr.2004.04.005.