Onodera Taishi, Poe Jonathan C, Tedder Thomas F, Tsubata Takeshi
Laboratory of Immunology, School of Biomedical Science, Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
J Immunol. 2008 Jan 15;180(2):907-13. doi: 10.4049/jimmunol.180.2.907.
Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."
由于病原体以时间依赖性方式诱导感染症状，快速的免疫反应有利于保护宿主抵御病原体，尤其是那些引发急性传染病的病原体。然而，免疫反应的时间进程如何被调节在很大程度上尚不清楚。在本研究中，我们证明缺乏抑制性共受体CD22的B细胞在抗原刺激后经历加速的细胞分裂，导致浆细胞的快速产生和抗体产生。这一发现表明CD22调节B细胞反应的时间进程，并提示CD22是缩短抗体产生所需时间的良好靶点，从而作为“通用疫苗接种”增强宿主对急性传染病的防御。
