Zdravkovic Slobodan, Wienke Andreas, Pedersen Nancy L, de Faire Ulf
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Twin Res Hum Genet. 2007 Dec;10(6):848-52. doi: 10.1375/twin.10.6.848.
The aim of this study was to determine the influence of genetic factors on the first episode of acute myocardial infarction. Probandwise concordances, tetrachoric correlations and quantitative genetic analyses of liability were applied to data drawn from the Swedish Twin Registry and the Swedish Acute Myocardial Infarction Register. All same-sexed twin pairs born between 1886 and 1958 who were alive in 1987 were included in the analyses. Our results show that concordance rates for acute myocardial infarction in monozygotic (MZ) twins were similar across sexes (among males .26 and females .27). For dizygotic (DZ) twins the concordances were .20 for males and .16 for females, yielding a greater MZ-DZ concordance differential for females than males. Tetrachoric correlations were greater for MZ than DZ twins for both sexes (.49 for male MZ and .34 for male DZ-twins and .56 and .35 for female MZ and DZ twins respectively). Quantitative genetic analyses of liability resulted in equal variance components for males and females (.36) but significantly different thresholds (prevalences). In conclusion, liability to first occurrence of acute myocardial infarction is moderately influenced by genetic variants in both sexes. The familial influence on phenotypic variance is exclusively explained by additive genetic factors.
本研究的目的是确定遗传因素对急性心肌梗死首发事件的影响。对来自瑞典双胞胎登记处和瑞典急性心肌梗死登记处的数据应用了先证者一致性、四分相关和易感性的定量遗传分析。分析纳入了所有在1886年至1958年之间出生且在1987年仍在世的同性双胞胎对。我们的结果表明，单卵（MZ）双胞胎中急性心肌梗死的一致率在性别间相似（男性为0.26，女性为0.27）。对于双卵（DZ）双胞胎，男性的一致率为0.20，女性为0.16，女性的MZ-DZ一致率差异大于男性。两性中MZ双胞胎的四分相关均大于DZ双胞胎（男性MZ为0.49，男性DZ为0.34，女性MZ和DZ分别为0.56和0.35）。易感性的定量遗传分析得出男性和女性的方差成分相等（0.36），但阈值（患病率）显著不同。总之，急性心肌梗死首次发生的易感性在两性中均受到遗传变异的中度影响。家族对表型变异的影响完全由加性遗传因素解释。
