Bilginer Yelda, Ozaltin Fatih, Duzova Ali, Erdogan Ilkay, Aki Tuncay Fazil, Demircin Metin, Bakkaloglu Mehmet, Bakkaloglu Aysin
Department of Pediatric Nephrology, Hacettepe Unviersity Faculty of Medicine, Ankara, Turkey.
Pediatr Transplant. 2008 Mar;12(2):251-5. doi: 10.1111/j.1399-3046.2007.00857.x. Epub 2007 Dec 26.
Nephrotic syndrome represents a form of acquired thrombophilia thereby causing increased risk of thrombosis. In patients with nephrotic syndrome both venous and arterial thrombosis can occur; however, intracardiac thrombus is among the rarest reported in the literature. In this case report, we present a 10.5-yr-old boy with right atrial thrombosis and an acute rejection episode after renal transplantation due to end stage renal disease caused by focal segmental glomerulosclerosis manifested by nephrotic syndrome. The clinical course was successfully managed with surgical removal of thrombus, institution of anticoagulant as well as antirejection therapy. This report draws attention to the risks that could be associated with thrombosis in renal recipients with congenital or acquired thrombophilias and emphasizes the importance of identifying risk factors for thrombosis in these patients.
肾病综合征是一种获得性血栓形成倾向的形式，从而导致血栓形成风险增加。在肾病综合征患者中，静脉和动脉血栓均可发生；然而，心内血栓是文献报道中最罕见的情况之一。在本病例报告中，我们介绍了一名10.5岁男孩，因局灶节段性肾小球硬化导致终末期肾病并表现为肾病综合征，在肾移植后出现右心房血栓和急性排斥反应。通过手术清除血栓、使用抗凝剂以及抗排斥治疗，成功控制了临床病程。本报告提请注意先天性或获得性血栓形成倾向的肾移植受者中可能与血栓形成相关的风险，并强调识别这些患者血栓形成危险因素的重要性。
