[3型登革热患者的血清转氨酶水平]

[Aminotransferases serum levels in patients with Dengue type 3].

作者信息

Valero C Nereida, Reyes V Ivette, Larreal E Yraima, Maldonado E Mery

机构信息

Sección de Virología, Instituto de Investigaciones Clínicas Dr. Américo Negrette, Universidad del Zulia, Maracaibo, Zulia, Venezuela.

出版信息

Rev Med Chil. 2007 Oct;135(10):1304-12. Epub 2007 Dec 20.

PMID:18180838

Abstract

BACKGROUND

Dengue infections may affect the liver, causing inflammation and compromising its function.

AIM

To determine serum aminotransferases in patients with Dengue.

MATERIAL AND METHODS

One hundred eighty four patients with Dengue confirmed with anti-Dengue IgG and IgM antibodies measured by ELISA, aged 1 month to 79 years, were studied. As controls, 40 patients with acute hepatitis B virus infection aged 11 to 59 years and 40 healthy individuals, aged 14 to 55 years, were also studied. Alanine and aspartate aminotransferases (ALT and AST) were determined using a colorimetric method.

RESULTS

Sixty one percent of patients with Dengue had elevated aminotransferase levels. In patients with Dengue and hepatitis B, mean ALT levels were 21.3+/-8.4 and 29.7+/-18.8 U/I, respectively. Mean AST values were 37.3+/-19, 19.6+/- 16.4 and 4.3+/-1.7 U/I in patients with Dengue, hepatitis B and controls, respectively. During the year 2001, there was an increase in the number of cases with hemorrhagic fever caused by Dengue and 65% had elevation of aminotransferases.

CONCLUSIONS

An increase in aminotransf erase levels is common in patients with Dengue.

摘要

背景

登革热感染可能会影响肝脏，引发炎症并损害其功能。

目的

测定登革热患者的血清转氨酶水平。

材料与方法

对184例经酶联免疫吸附测定法（ELISA）确诊为抗登革热IgG和IgM抗体阳性、年龄在1个月至79岁之间的登革热患者进行了研究。作为对照，还研究了40例年龄在11至59岁之间的急性乙型肝炎病毒感染患者以及40例年龄在14至55岁之间的健康个体。采用比色法测定丙氨酸和天冬氨酸转氨酶（ALT和AST）水平。

结果

61%的登革热患者转氨酶水平升高。登革热患者和乙型肝炎患者的平均ALT水平分别为21.3±8.4和29.7±18.8 U/I。登革热患者、乙型肝炎患者和对照组的平均AST值分别为37.3±19、19.6±16.4和4.3±1.7 U/I。2001年，登革热引起的出血热病例数有所增加，65%的患者转氨酶升高。