Guillevin Loïc
Service de Médecine Interne, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris René Descartes, 27 rue du Faubourg Saint-Jacques, Paris, France.
Clin Rev Allergy Immunol. 2008 Oct;35(1-2):72-8. doi: 10.1007/s12016-007-8068-4.
Necrotizing systemic vasculitides are severe diseases in which prognosis improved since steroids and cytotoxic agents have been prescribed. The outcome is now better, and remission is obtained in more than 80% of patients. In this review paper, we will cover the indications of conventional treatments and new biotherapies and other therapies. The strategies that improve patient's outcome are discussed in the light of the prospective trials organized by international research groups.
坏死性系统性血管炎是严重疾病,自从使用类固醇和细胞毒性药物以来,其预后有所改善。现在结果更好,超过80%的患者可实现缓解。在这篇综述论文中,我们将涵盖传统治疗、新生物疗法及其他疗法的适应证。根据国际研究小组组织的前瞻性试验,讨论了改善患者预后的策略。