Rasminsky M
Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada.
J Physiol (Paris). 1991;85(3):171-8.
The responses to light of retinal ganglion cells with regenerated axons can be recorded from axons teased from peripheral nerve grafts replacing the optic nerve of the adult rat or hamster. These responses resemble those of normal retinal ganglion cells but can no longer be observed several months after grafting, concomitant with ongoing loss of the population of axotomized retinal ganglion cells. Synapses formed with neurons in the superior colliculus by retinal ganglion cell axons regenerated through peripheral nerve grafts mediate both excitatory and inhibitory responses. These experiments demonstrate that when provided with an appropriate milieu for elongation, neurons indigenous to the adult mammalian central nervous system can make functional reconnections with distant targets within the nervous system.
对于成年大鼠或仓鼠视神经被外周神经移植物替代后从外周神经移植物中分离出的轴突上再生轴突的视网膜神经节细胞的光反应可以进行记录。这些反应类似于正常视网膜神经节细胞的反应，但在移植后几个月就不再能观察到，同时伴随着轴突切断的视网膜神经节细胞群体的持续丧失。通过外周神经移植物再生的视网膜神经节细胞轴突与上丘中的神经元形成的突触介导兴奋和抑制反应。这些实验表明，当为其提供适合伸长的环境时，成年哺乳动物中枢神经系统的固有神经元可以与神经系统内的远距离靶标建立功能性重新连接。
