体外肺辅助期间血小板聚集的抑制：一例报告

Inhibition of thrombocyte aggregation during extracorporeal lung assist: a case report.

作者信息

Philipp Alois, Müller Thomas, Bein Thomas, Foltan Maik, Schmid Franz-Xaver, Birnbaum Dietrich, Schmid Christof

机构信息

Department of Cardiothoracic Surgery, University Hospital of Regensburg, Regensburg, Germany.

出版信息

Perfusion. 2007 Jul;22(4):293-7. doi: 10.1177/0267659107083244.

DOI:10.1177/0267659107083244

PMID:18181519

Abstract

In extracorporeal lung assist, membrane oxygenators are used to improve gas exchange. Accumulations on the membranes of coagulation end products can increase resistance to blood flow and diffusion distance. Thus, functioning of the system can be impaired and, in extreme cases, lead to malfunction which may necessitate change out of the oxygenator. We describe a method that complements conventional continuous heparinisation with the administration of acetylsalicylic acid to inhibit thrombocyte aggregation.

摘要

在体外肺辅助中，膜式氧合器用于改善气体交换。凝血终产物在膜上的积聚可增加血流阻力和扩散距离。因此，该系统的功能可能会受损，在极端情况下，会导致故障，可能需要更换氧合器。我们描述了一种方法，即通过给予乙酰水杨酸来补充传统的持续肝素化，以抑制血小板聚集。