Philipp Alois, Wiesenack Christoph, Behr Renate, Schmid Franz X, Birnbaum Dietrich E
Clinic for Cardiothoracic Surgery, University of Regensburg, Germany.
Perfusion. 2002 May;17(3):175-8. doi: 10.1191/0267659102pf566oa.
In cardiac surgery with the aid of extracorporeal circulation (ECC), inhalation anaesthetics can be administered via the oxygenator. Until the recent advent of a new type of diffusion membrane oxygenator, we routinely added the inhalation agent, isoflurane, to the gas flow of a microporous capillary membrane-type oxygenator. Applying this procedure to the diffusion-type oxygenators, the depth of anaesthesia appeared to be affected, which manifested itself through unusually high intraoperative perfusion pressures. This observation led to a prospective randomized study comprising 60 patients and two models of a microporous capillary membrane oxygenator, as well as two models of a diffusion membrane oxygenator. Simultaneous isoflurane concentration measurements at both the gas inlet and outlet ports of the oxygenators showed that, whereas in the microporous capillary-type oxygenators the isoflurane administered was reduced by about 50% during the passage of gas through the device, there was only a minimal transfer of isoflurane in the diffusion-type membrane oxygenators.
在体外循环（ECC）辅助下的心脏手术中，吸入麻醉剂可通过氧合器给药。直到新型扩散膜氧合器出现之前，我们通常将吸入剂异氟烷添加到微孔毛细血管膜式氧合器的气流中。将此方法应用于扩散型氧合器时，麻醉深度似乎受到影响，表现为术中灌注压力异常高。这一观察结果导致了一项前瞻性随机研究，该研究包括60名患者以及两种微孔毛细血管膜氧合器模型和两种扩散膜氧合器模型。在氧合器的气体入口和出口端口同时进行异氟烷浓度测量表明，在微孔毛细血管型氧合器中，气体通过该装置时所给予的异氟烷减少了约50%，而在扩散型膜氧合器中，异氟烷的转移量极小。
