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[用苏联制剂阿齐诺克治疗华支睾吸虫病的首次试验]

[The first trial of treating opisthorchiasis with the Soviet preparation azinoks].

作者信息

Stepanova T F, Pomigalov A Iu, Shonin A L, Postnikova T F, Emel'ianova E D, Maĭer V A, Skarednov N I

出版信息

Med Parazitol (Mosk). 1991 Nov-Dec(6):30-2.

PMID:1818244
Abstract

7 patients in the acute and 51 patients in the chronic stages of opisthorchiasis were treated with azynoks in daily dose 60 mg per kilo. The radical cure was achieved in 95.8 +/- 0.4% of cases. The wild side effects (headache, vertigo, nausea, fatigue) were registered in 51.7 +/- 9.1% of the cases, predominantly during the first hours of the treatment. The biochemical and immunological changes during the first 2 weeks after azynoks administration were analogues to those seen after biltricide and chloxyl (hexaparaxylol) treatment.

摘要

7例急性华支睾吸虫病患者和51例慢性华支睾吸虫病患者接受了阿嗪诺克治疗,每日剂量为每公斤60毫克。95.8±0.4%的病例实现了根治。51.7±9.1%的病例出现了不良反应(头痛、眩晕、恶心、疲劳),主要发生在治疗的最初几个小时。服用阿嗪诺克后前两周的生化和免疫变化与服用吡喹酮和氯氧喹(己二对甲酚)治疗后的变化相似。

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