Mikhaĭlitsyn F S, Lebedeva M N, Baiandina D G, Kozyreva N P, Lychko N D, Bolotina L A, Drusviatskaia S K, Naĭdenova A S
Med Parazitol (Mosk). 1991 Nov-Dec(6):52-3.
The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.
本文介绍了28种低毒含卤磺酰胺基苯甲酰胺新化合物的临床前试验结果。在膜壳绦虫病模型试验中，N-(2,5-二氯苯基)-2/（3-硝基-4-氯苯基）磺酰氨基/-5-溴苯甲酰胺的有效性与知名药物氯硝柳胺相似。在华支睾吸虫病模型试验中，有2种化合物显示出高效性，在鞭虫病模型试验中有5种化合物表现出高活性。
