[戊四氮点燃大鼠海马苔藓纤维发芽的变化]
[Changes of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats].
作者信息
Tian Fa-fa, Guo Ting-hui, Chen Jin-mei, Ma Yun-feng, Cai Xiao-feng, Yao Feng-hong
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Dec;32(6):1026-30.
OBJECTIVE
To determine the changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats of chronic epilepsy induced by pentylenetetrazole (PTZ).
METHODS
Sixty rats were randomly divided into a control group and a PTZ group (PTZ 30 mg/kg, intraperitoneal injection, once daily). The changes of mossy fiber sprouting in hippocampus of pre-kindling and post-kindling rats were examined by Timm staining.
RESULTS
Before the occurrence of convulsion confirmed by behavior and EEG, the mossy fiber sprouting was found in the PTZ group. The grade of the mossy fiber sprouting increased with the gradual establishment of kindling effect.
CONCLUSION
Mossy fiber sprouting may play an important role in the onset and development of epilepsy.
目的
确定戊四氮（PTZ）诱导的慢性癫痫点燃前和点燃后大鼠海马苔藓纤维发芽的变化。
方法
将60只大鼠随机分为对照组和PTZ组（PTZ 30mg/kg，腹腔注射，每日1次）。通过Timm染色检查点燃前和点燃后大鼠海马苔藓纤维发芽的变化。
结果
在行为和脑电图证实惊厥发作前，PTZ组发现有苔藓纤维发芽。苔藓纤维发芽程度随点燃效应的逐渐建立而增加。
结论
苔藓纤维发芽可能在癫痫的发生和发展中起重要作用。
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