Pimenova T I
Patol Fiziol Eksp Ter. 1991(6):16-8.
The study was performed on 20 male rabbits. The effect of intravenous delta-sleep-inducing peptide (DSIP), 60 nmol/kg in 5 ml of saline, on central hemodynamic parameters was studied in 11 experiments. Nine rabbits formed the control group. Two heterodirectional responses of the heart and vessels occurred in the animals given DSIP, which made them divide into 2 groups: those with a predominantly cardiac type of hemodynamic responses (n = 5) and animals with a predominantly vascular type of hemodynamic responses (n = 6). The results of the studies showed that DSIP affected central hemodynamics of intact animals; a direct action of DSIP on the vascular tone and permeability as well as on myocardial contractility cannot be excluded. The changes in hemodynamic parameters were, however, within the physiological normal range.
该研究以20只雄性兔子为实验对象。在11次实验中，研究了静脉注射5毫升生理盐水中含60纳摩尔/千克的δ-睡眠诱导肽（DSIP）对中心血流动力学参数的影响。9只兔子作为对照组。给予DSIP的动物出现了心脏和血管的两种相反方向的反应，这使得它们被分为两组：血流动力学反应以心脏型为主的动物（n = 5）和血流动力学反应以血管型为主的动物（n = 6）。研究结果表明，DSIP影响了完整动物的中心血流动力学；不能排除DSIP对血管张力和通透性以及心肌收缩力的直接作用。然而，血流动力学参数的变化在生理正常范围内。
