Vanholder R, Meert N, Schepers E, Glorieux G
Nephrology Section, University Hospital, Gent, Belgium.
Blood Purif. 2008;26(1):77-81. doi: 10.1159/000110570. Epub 2008 Jan 10.
The uremic syndrome is characterized by a complex clinical picture, whereby the function of multiple organ systems is affected by the retention of a host of solutes. Recent research of the last decade has helped to unravel multiple pathophysiologic mechanisms and to identify as yet unknown responsible compounds.
The literature was screened to appreciate which compounds play the most important pathophysiologic role.
The picture that ensues is that the main role is played by molecules which are so-called 'difficult to remove by dialysis'. The knowledge of uremic toxicity is still far from complete and we need extra information about responsible compounds and mechanisms, eventually leading to a classification of the most important culprits, to allow the development of efficient removal strategies and of pharmacologic methods to counteract pathophysiologic mechanisms.
Uremic retention is a complex phenomenon and the most toxic compounds are difficult to remove by dialysis. Furthermore, our knowledge of the responsible pathways is still incomplete, and needs to be extended to develop new and more efficient treatment strategies.
尿毒症综合征具有复杂的临床表现，多个器官系统的功能受到多种溶质潴留的影响。过去十年的最新研究有助于揭示多种病理生理机制，并识别出迄今未知的相关化合物。
对文献进行筛选，以了解哪些化合物在病理生理中发挥最重要作用。
由此得出的情况是，主要作用由所谓“难以通过透析清除”的分子发挥。关于尿毒症毒性的知识仍远未完善，我们需要有关相关化合物和机制的更多信息，最终对最重要的致病因素进行分类，以便制定有效的清除策略和对抗病理生理机制的药理学方法。
尿毒症潴留是一种复杂现象，毒性最强的化合物难以通过透析清除。此外，我们对相关途径的了解仍不完整，需要加以扩展以制定新的、更有效的治疗策略。
