Pietrogrande Luca
Orthopedic Clinic, DMCO San Paolo, University of Milano, Milano, Italy.
Aging Clin Exp Res. 2007 Aug;19(4 Suppl):26-9.
Severe osteoporosis, a situation with fractures, can worsen in the case of poor response to usual therapies, such as bisphosphonates associated with calcium and vitamin D, especially if bone turnover is strongly suppressed. One way of inverting the poor evolution of non-responders is to use Teriparatide. The case of a non-responder is reported, with considerations about the possibility of detecting these patients before a new fracture takes place.
严重骨质疏松症，一种伴有骨折的情况，在对常规治疗（如与钙和维生素D联合使用的双膦酸盐）反应不佳时可能会恶化，尤其是在骨转换被强烈抑制的情况下。扭转无反应者不良病情发展的一种方法是使用特立帕肽。本文报告了一例无反应者的病例，并探讨了在新骨折发生前检测出这些患者的可能性。
