Segura Marcela, Sosa Estani Sergio, Marone Rubén, Bautista Christian T, Pando María A, Eyzaguirre Lindsay, Sánchez José L, Carr Jean K, Montano Silvia M, Weissenbacher Mercedes, Avila María M
Centro Nacional de Referencia para el SIDA, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
AIDS Res Hum Retroviruses. 2007 Nov;23(11):1322-9. doi: 10.1089/aid.2007.0063.
The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (> or =10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.
通过一项前瞻性队列研究，评估了男男性行为者（MSM）中HIV-1感染的患病率、发病率、危险因素和分子基因分型。该研究于2003年2月至2004年12月在布宜诺斯艾利斯进行。在基线以及6个月和12个月时收集社会人口统计学、性风险行为数据以及用于HIV检测的血样。应用Cox回归分析来确定与HIV血清转化相关的危险因素。对HIV阳性样本进行部分（pro/RT）和全长基因组测序分析。在基线时评估的811名HIV阴性参与者中，327名符合纳入标准的志愿者被纳入研究。6个月和12个月时的保留率分别为97.2%和91.5%。12名MSM发生了HIV感染血清转化[发病率=每100人年3.9（95%CI=2.0-6.7）]。HIV血清转化与前6个月更多不同的性接触相关（≥10次，风险比=3.3，95%CI：1.1-10.4）。通过部分pro/RT基因分型分析，83%的HIV阳性样本为B亚型，17%的样本为BF重组体，其中大多数是独特的重组形式。本研究首次描述了阿根廷一组MSM的招募和随访情况。保留率和HIV发病率都很高。这些数据应被视为HIV疫苗试验有前景的潜在人群。
