Use of Doppler's echocardiography for the examination of Nitromint spray in coronary disease patients and in patients who underwent coronary bypass surgery.

The changes of "E" and "A" waves of mitral inflow have been measured before, and 1,2,3,5 and 10 minutes after the use of Nitromint spray (EGIS) in coronary disease patients (14 cases), and in patients who had undergone bypass surgery (7 cases), by pulsatile wave Doppler's echocardiography. The "E" wave gave more information on the preload decreasing effect of the drug, than the "A" wave (significant decrease in minutes 1,2,3,5 and 10 following spraying). On the basis of the changes of the "E" wave compared in the two patient groups a difference in the responses to Nitromint spray could be revealed: the non-operated coronary disease patients responded with a more marked decrease of preload to Nitromint spray than the revascularize patients.