Hashimoto Masaya, Kawasaki Keiichi, Suzuki Masahiko, Mitani Kazuko, Murayama Shigeo, Mishina Masahiro, Oda Keiichi, Kimura Yuichi, Ishiwata Kiichi, Ishii Kenji, Inoue Kiyoharu
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Neuroreport. 2008 Jan 22;19(2):145-50. doi: 10.1097/WNR.0b013e3282f3e3d8.
A simultaneous evaluation of presynaptic and postsynaptic dopaminergic positron emission tomography markers, the dopamine transporters and the dopamine D2-like receptors, was performed in eight patients with parkinsonian phenotype of multiple system atrophy. Both presynaptic and postsynaptic markers were revealed to have declined in such a manner that they kept strong positive correlation throughout the striatum of all patients, suggesting that the degeneration process in the striatum may involve the entire structure of the dopaminergic synapse. In two L-3,4,dihydroxyphenyl-alanine-responsive cases, the balance of decline in two markers was relatively shifted to presynaptic dominant side. Correlative positron emission tomography study of presynaptic and postsynaptic dopaminergic function may be useful for the diagnosis of multiple system atrophy and to understand the mechanisms of its temporal L-3,4,dihydroxyphenyl-alanine responsiveness.
对8例具有多系统萎缩帕金森综合征表型的患者进行了突触前和突触后多巴胺能正电子发射断层扫描标记物（多巴胺转运体和多巴胺D2样受体）的同步评估。结果显示，突触前和突触后标记物均有所下降，且在所有患者的纹状体内始终保持着强正相关，这表明纹状体内的变性过程可能涉及多巴胺能突触的整个结构。在2例对左旋多巴有反应的病例中，两种标记物下降的平衡相对偏向突触前占优势的一侧。突触前和突触后多巴胺能功能的相关正电子发射断层扫描研究可能有助于多系统萎缩的诊断，并有助于理解其对左旋多巴反应的时间机制。
