接受锂盐治疗的双相情感障碍患者杏仁核和海马体体积增大。
Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium.
作者信息
Foland Lara C, Altshuler Lori L, Sugar Catherine A, Lee Agatha D, Leow Alex D, Townsend Jennifer, Narr Katherine L, Asuncion Dina M, Toga Arthur W, Thompson Paul M
机构信息
Laboratory of NeuroImaging, Department of Neurology, University of California, UCLA School of Medicine, Los Angeles, California, USA.
出版信息
Neuroreport. 2008 Jan 22;19(2):221-4. doi: 10.1097/WNR.0b013e3282f48108.
Previous structural neuroimaging studies of bipolar disorder have reported conflicting findings in limbic structures. Medication heterogeneity of patient samples may have contributed to these inconsistencies. Using structural magnetic resonance imaging we assessed whether lithium treatment was associated with differences in amygdala and hippocampal volumes in a sample of bipolar adults. A total of 49 magnetic resonance imaging scans were collected from patients who were currently treated with or without lithium. Amygdala and hippocampal volumes were analyzed using tensor-based morphometry. Statistical between-group comparisons of deformation maps showed that patients treated with lithium exhibited significantly increased volumes of the amygdala and hippocampus compared with patients who were not taking lithium. Our findings may help to explain previous inconsistencies in the bipolar literature.
先前关于双相情感障碍的结构神经影像学研究报告了边缘系统结构中相互矛盾的结果。患者样本的药物异质性可能导致了这些不一致性。我们使用结构磁共振成像来评估锂治疗是否与双相情感障碍成年患者样本中杏仁核和海马体积的差异有关。我们从正在接受或未接受锂治疗的患者中总共收集了49份磁共振成像扫描数据。使用基于张量的形态测量法分析杏仁核和海马体积。变形图的组间统计比较显示，与未服用锂的患者相比，接受锂治疗的患者杏仁核和海马体积显著增加。我们的研究结果可能有助于解释双相情感障碍文献中先前的不一致性。
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