Akbay Ercan, Arbağ Hamdi, Uyar Yavuz, Oztürk Kayhan
Department of Otolaryngology, Bingöl State Hospital, Bingöl, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2007;17(4):189-96.
We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis.
The study included 40 patients (13 males, 27 females; mean age 30+/-14 years; range 4 to 63 years) with allergic rhinitis. The mean symptom duration was 5.2+/-4.9 years. Blood and serum samples were analyzed spectrophotometrically. Myeloperoxidase (MPO) activity and vitamins A and E were measured as enzymatic and non-enzymatic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde (MDA) level. Total antioxidant capacity (TAC) was measured as the total antioxidant activity against oxidative stress products. The results were compared with those of a control group consisting of 40 healthy individuals.
Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were significantly lower in the patient group (p<0.05).
Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.
我们评估了氧化应激和抗氧化剂在变应性鼻炎发病机制中的作用。
该研究纳入了40例变应性鼻炎患者（男性13例，女性27例；平均年龄30±14岁；范围4至63岁）。平均症状持续时间为5.2±4.9年。采用分光光度法对血液和血清样本进行分析。分别测定髓过氧化物酶（MPO）活性以及维生素A和E，作为酶促抗氧化剂和非酶促抗氧化剂。通过丙二醛（MDA）水平确定氧化应激。测量总抗氧化能力（TAC），作为针对氧化应激产物的总抗氧化活性。将结果与由40名健康个体组成的对照组进行比较。
与对照组相比，患者组的平均MDA水平显著更高，而平均MPO、维生素A和E水平以及TAC显著更低（p<0.05）。
我们的结果表明，氧化应激与抗氧化防御机制之间的失衡可能在变应性鼻炎的发病机制中起作用。
