DeBry Spencer C, Tiffany Stephen T
University of Utah Department of Psychiatry, Salt Lake City, UT 84132, USA.
Nicotine Tob Res. 2008 Jan;10(1):11-25. doi: 10.1080/14622200701767811.
Early initiation of cigarette use is associated with higher levels of nicotine dependence. This paper provides a theory to explain this finding based on the neurotoxic effects of cigarettes on a developing system. The tobacco-induced neurotoxicity of adolescent cognitive development (TINACD) theory postulates that alterations in executive functioning, particularly evident under stressful or emotionally intense states, lead to higher levels of dependence. The model proposes that the neurotoxic effects of tobacco are most pronounced when smoking begins during early adolescence, a period of major neurodevelopment subserving inhibitory control.
早期开始吸烟与更高水平的尼古丁依赖有关。本文基于香烟对发育中的系统的神经毒性作用，提供了一种理论来解释这一发现。青少年认知发展的烟草诱导神经毒性（TINACD）理论假定，执行功能的改变，在压力或情绪强烈状态下尤为明显，会导致更高水平的依赖。该模型提出，当在青春期早期开始吸烟时，烟草的神经毒性作用最为显著，青春期早期是主要的神经发育阶段，负责抑制控制。
