Hashimoto Takao
Jules Stein Eye Institute, University of California Los Angeles, CA 90095, U.S.A.
Adv Exp Med Biol. 2008;613:113-9. doi: 10.1007/978-0-387-74904-4_12.
Striving for ideal viral constructs by modifying its structure, including promoters, would make the viral gene therapy more promising. Further assessment of the promoters and their expression profiles such as those shown in Table 1 and new designs of hybrid promoters may achieve optimal expression features for ocular gene therapies.
通过修饰病毒结构（包括启动子）来构建理想的病毒载体，将使病毒基因治疗更具前景。对启动子及其表达谱（如表1所示）进行进一步评估以及设计新型杂交启动子，可能会实现眼部基因治疗的最佳表达特性。
