Takaoka Akinori, Tamura Tomohiko, Taniguchi Tadatsugu
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Cancer Sci. 2008 Mar;99(3):467-78. doi: 10.1111/j.1349-7006.2007.00720.x. Epub 2008 Jan 9.
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)-alpha/beta system. The IRF family has now expanded to nine members, and gene-disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor suppression. In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis.
一类转录因子,即干扰素调节因子(IRF),最初是在I型干扰素(IFN)-α/β系统的调节背景下被鉴定出来的。IRF家族现已扩展到九个成员,基因敲除研究表明这些成员在宿主防御系统的多个方面发挥着关键作用,如先天性和适应性免疫反应以及肿瘤抑制。在本综述文章中,我们旨在总结目前关于IRF在宿主防御中的作用的知识,特别强调它们在肿瘤发生调节中的作用。