重新审视IRF家族。
The IRF family, revisited.
作者信息
Paun A, Pitha P M
机构信息
Division of Viral Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
出版信息
Biochimie. 2007 Jun-Jul;89(6-7):744-53. doi: 10.1016/j.biochi.2007.01.014. Epub 2007 Feb 20.
Abstract
Since the discovery of interferon 50 years ago a great deal of progress has been made in understanding how interferons work and how and why they are induced. Key factors in interferon induction are the interferon regulatory factors (IRF). In this review of IRF we aim to show you not only the historical side of the IRF but also the integral, anti-viral and hematopoetic roles of these transcription factors, as well as the sometimes surprising and even forgotten roles that these proteins play, not only in interferon signaling but throughout the immune system and the body as a whole. Further research will no doubt expand the repertoire of these multifunctional proteins even more.
摘要
自50年前发现干扰素以来，在理解干扰素如何发挥作用以及它们如何、为何被诱导方面已经取得了很大进展。干扰素诱导的关键因素是干扰素调节因子（IRF）。在这篇关于IRF的综述中，我们旨在向您展示的不仅是IRF的历史方面，还有这些转录因子在整体、抗病毒和造血方面的作用，以及这些蛋白质所发挥的有时令人惊讶甚至被遗忘的作用，不仅在干扰素信号传导中，而且在整个免疫系统和整个身体中。毫无疑问，进一步的研究将进一步扩大这些多功能蛋白质的种类。
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