Guitard Juliette, Cottrell Gilles, Magnouha Nellie Moulopo, Salanti Ali, Li Tengfei, Sow Sokhna, Deloron Philippe, Tuikue Ndam Nicaise
Institut de Recherche pour le Développement (IRD), UR010, Mother and Child Health in the Tropics, Université Paris Descartes, France.
Malar J. 2008 Jan 11;7:10. doi: 10.1186/1475-2875-7-10.
Pregnant women develop protective anti-VSA IgG1 and IgG3 when infected by Plasmodium falciparum. The major target of IgG from serum of infected pregnant women is VAR2CSA.
In this study, ELISA was used to compare the level of VAR2CSA DBL5epsilon- specific IgG subclasses at enrolment and at delivery in a cohort of pregnant women in Senegal. All antibody measures were analysed in relation to placental infection according to parity.
The results show an interaction between immune response to placental malaria and parity. A higher level of anti- DBL5epsilon- IgG3 at enrolment and a higher increase between enrolment and delivery were found in primigravidae who presented with uninfected placenta at delivery in comparison to those who presented with an infection of the placenta. However, high antibody level at delivery was associated with the infection of the placenta in multigravidae.
This high level of IgG3 in uninfected primigravidae suggests a protective role of these antibodies in this susceptible group, highlighting the importance of VAR2CSA in general and of some of its variants still to be defined, in the induction of protective immunity to pregnancy malaria.
孕妇感染恶性疟原虫后会产生保护性抗VSA IgG1和IgG3。感染孕妇血清中IgG的主要靶标是VAR2CSA。
在本研究中，采用酶联免疫吸附测定法（ELISA）比较了塞内加尔一组孕妇在入组时和分娩时VAR2CSA DBL5ε特异性IgG亚类的水平。根据产次，分析了所有抗体测量值与胎盘感染的关系。
结果显示胎盘疟疾免疫反应与产次之间存在相互作用。与分娩时胎盘感染的初产妇相比，分娩时胎盘未感染的初产妇在入组时抗DBL5ε - IgG3水平更高，且入组至分娩期间升高幅度更大。然而，经产妇分娩时抗体水平高与胎盘感染有关。
未感染的初产妇中这种高水平的IgG3表明这些抗体在该易感群体中具有保护作用，突出了VAR2CSA总体上以及某些尚待确定的变体在诱导对妊娠疟疾的保护性免疫中的重要性。
Zotero 插件