乳腺肿瘤血管生成
Breast tumour angiogenesis.
作者信息
Fox Stephen B, Generali Daniele G, Harris Adrian L
机构信息
Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, 3002, Australia.
出版信息
Breast Cancer Res. 2007;9(6):216. doi: 10.1186/bcr1796.
Abstract
The central importance of tumour neovascularization has been emphasized by clinical trials using antiangiogenic therapy in breast cancer. This review gives a background to breast tumour neovascularization in in situ and invasive breast cancer, outlines the mechanisms by which this is achieved and discusses the influence of the microenvironment, focusing on hypoxia. The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized.
摘要
使用抗血管生成疗法治疗乳腺癌的临床试验已强调了肿瘤新生血管形成的核心重要性。本综述介绍了原位和浸润性乳腺癌中乳腺肿瘤新生血管形成的背景，概述了实现这一过程的机制，并讨论了微环境的影响，重点是缺氧。还总结了血管生成的调节以及用于抗血管生成给药方案的抗血管生成药物，包括新型和传统药物。
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本文引用的文献
1
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization.
Genes Dev. 2007 Jun 15;21(12):1546-58. doi: 10.1101/gad.436307.
2
Biologic properties of endothelial progenitor cells and their potential for cell therapy.
Prog Cardiovasc Dis. 2007 May-Jun;49(6):421-9. doi: 10.1016/j.pcad.2007.02.004.
3
HIF-1 and HIF-2: working alone or together in hypoxia?
J Clin Invest. 2007 Apr;117(4):862-5. doi: 10.1172/JCI31750.
4
Drug insight: VEGF as a therapeutic target for breast cancer.
Nat Clin Pract Oncol. 2007 Mar;4(3):181-9. doi: 10.1038/ncponc0740.
5
Vascular endothelial growth factor (VEGF) signaling in tumor progression.
Crit Rev Oncol Hematol. 2007 Jun;62(3):179-213. doi: 10.1016/j.critrevonc.2007.01.006. Epub 2007 Feb 26.
6
Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.
Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
7
Monocyte-macrophage system as a target for estrogen and selective estrogen receptor modulators.
Ann N Y Acad Sci. 2006 Nov;1089:218-27. doi: 10.1196/annals.1386.045.
8
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.
Int J Cancer. 2007 Apr 1;120(7):1451-8. doi: 10.1002/ijc.22436.
9
Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.
Am J Pathol. 2007 Jan;170(1):1-15. doi: 10.2353/ajpath.2007.060302.
10
The prognostic value of vascular endothelial growth factors (VEGFs)-A and -B and their receptor, VEGFR-1, in invasive breast carcinoma.
Gynecol Oncol. 2007 Mar;104(3):557-63. doi: 10.1016/j.ygyno.2006.09.031. Epub 2006 Dec 5.
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