Feldman Adam S, McDougal W Scott, Harisinghani Mukesh G
Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA.
Urol Oncol. 2008 Jan-Feb;26(1):65-73. doi: 10.1016/j.urolonc.2007.03.016.
Accurate lymph node staging in genitourinary malignancy is an important component in the diagnostic algorithm and therapeutic planning. A promising new method for lymph node staging is lymphotrophic nanoparticle enhanced magnetic resonance imaging. This novel technique uses ultrasmall superparamagnetic iron oxide particles, which localize in lymph nodes and provide detailed characterization of these nodes independent of typically accepted size criteria. This review provides a brief overview of the presently accepted methods for noninvasive lymph node staging and thoroughly discusses lymphotrophic nanoparticle enhanced MR imaging: a technique that can be used for accurate detection of lymph node metastases and will likely play a major role in noninvasive lymph node staging in genitourinary cancer in the near future.
泌尿生殖系统恶性肿瘤中准确的淋巴结分期是诊断流程和治疗规划的重要组成部分。一种有前景的淋巴结分期新方法是嗜淋巴纳米颗粒增强磁共振成像。这项新技术使用超小超顺磁性氧化铁颗粒，这些颗粒定位于淋巴结，并能独立于通常认可的大小标准对这些淋巴结进行详细表征。本文综述简要概述了目前公认的非侵入性淋巴结分期方法，并深入讨论了嗜淋巴纳米颗粒增强磁共振成像：一种可用于准确检测淋巴结转移的技术，在不久的将来可能会在泌尿生殖系统癌症的非侵入性淋巴结分期中发挥主要作用。
