Thevis Mario, Kohler Maxie, Schänzer Wilhelm
Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany.
Drug Discov Today. 2008 Jan;13(1-2):59-66. doi: 10.1016/j.drudis.2007.11.003. Epub 2008 Jan 3.
The issue of doping in sport is multifaceted. New drugs not only with anabolic properties such as selective androgen receptor modulators, synthetic insulins, blood doping with erythropoietins or homologous and autologous blood transfusions but also with sample manipulation have necessitated sensitive, comprehensive and specific detection assays allowing for the identification of cheats. New methods based on mass spectrometry, flow cytometry and immunological techniques have been introduced and improved in the past years to support and enhance the antidoping fight. Although numerous approaches are successful and promising, these methods still have some shortcomings.
体育界的兴奋剂问题是多方面的。新型药物不仅包括具有合成代谢特性的药物，如选择性雄激素受体调节剂、合成胰岛素、使用促红细胞生成素进行血液兴奋剂或异体和自体输血，还包括样本操纵，这就需要灵敏、全面且特异的检测方法来识别作弊行为。在过去几年中，基于质谱、流式细胞术和免疫技术的新方法已被引入并得到改进，以支持和加强反兴奋剂斗争。尽管许多方法取得了成功且前景广阔，但这些方法仍存在一些缺点。
