恶病质治疗的新方法。
Novel approaches to the treatment of cachexia.
作者信息
Argilés Josep M, López-Soriano Francisco J, Busquets Sílvia
机构信息
Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain.
出版信息
Drug Discov Today. 2008 Jan;13(1-2):73-8. doi: 10.1016/j.drudis.2007.10.008. Epub 2007 Nov 26.
Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others. The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
恶病质是一种复杂的综合征。这种病理状态的主要组成部分是厌食和代谢异常，如葡萄糖不耐受、脂肪消耗以及肌肉蛋白分解代谢等。本文的目的是综述近期设计用于对抗不同病理状态（如癌症、艾滋病和慢性心力衰竭）下肌肉消耗的治疗方法。
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