Rubinstein Tamar, Pitashny Milena, Putterman Chaim
The Division of Rheumatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
Autoimmun Rev. 2008 Jan;7(3):229-34. doi: 10.1016/j.autrev.2007.11.013. Epub 2007 Dec 3.
Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses.
狼疮性肾炎是系统性红斑狼疮（SLE）的一种潜在破坏性后果，由于在严重肾损伤发生之前难以诊断其发病和识别复发，给SLE患者的管理带来了真正的挑战。中性粒细胞明胶酶 - B相关脂质运载蛋白（NGAL）/脂质运载蛋白 - 2与不同器官系统的几种疾病状态的发病机制有关，尤其是在肾脏疾病中。脂质运载蛋白 - 2可能通过铁转运依赖性机制诱导或预防细胞凋亡，在肾脏损伤的情况下发挥保护作用。临床上，尿脂质运载蛋白 - 2与狼疮性肾炎疾病活动度的测量值显著相关，可能是复发的一个重要且便捷的标志物。
