毒蕈碱受体在免疫和炎症反应调节中的作用。
Role of muscarinic receptors in the regulation of immune and inflammatory responses.
作者信息
Razani-Boroujerdi Seddigheh, Behl Muskaan, Hahn Fletcher F, Pena-Philippides Juan Carlos, Hutt Julie, Sopori Mohan L
机构信息
Immunology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States.
出版信息
J Neuroimmunol. 2008 Feb;194(1-2):83-8. doi: 10.1016/j.jneuroim.2007.11.019. Epub 2008 Jan 10.
Abstract
Leukocytes contain both nicotinic and muscarinic receptors, and while activation of nicotinic receptors suppresses immune/inflammatory responses, the role of muscarinic receptors in immunity is unclear. We examined the effects of a muscarinic receptor antagonist (atropine) and agonist (oxotremorine), administered chronically through miniosmotic pumps, on immune/inflammatory responses in the rat. Results show that while oxotremorine stimulated, atropine inhibited the antibody and T-cell proliferative responses. Moreover, atropine also suppressed the turpentine-induced leukocytic infiltration and tissue injury, and inhibited chemotaxis of leukocytes toward neutrophil and monocyte/lymphocyte chemoattractants. Thus, activation of nicotinic and muscarinic receptors has opposite effects on the immune/inflammatory responses.
摘要
白细胞同时含有烟碱型和毒蕈碱型受体，虽然烟碱型受体的激活会抑制免疫/炎症反应，但毒蕈碱型受体在免疫中的作用尚不清楚。我们研究了通过微型渗透泵长期给予毒蕈碱型受体拮抗剂（阿托品）和激动剂（氧化震颤素）对大鼠免疫/炎症反应的影响。结果表明，氧化震颤素具有刺激作用，而阿托品则抑制抗体和T细胞增殖反应。此外，阿托品还能抑制松节油诱导的白细胞浸润和组织损伤，并抑制白细胞向中性粒细胞和单核细胞/淋巴细胞趋化因子的趋化作用。因此，烟碱型和毒蕈碱型受体的激活对免疫/炎症反应具有相反的作用。
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